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In STEP 3, the first 8 weeks of the study consisted of a 1,000 kcal per day to 1,200 kcal per day liquid calorie diet at the discretion of the investigator, provided as meal replacements and portion-controlled meals

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Standard community protocols run tirzepatide alone for the first 8 weeks (2.5 5 mg/week) to confirm GI tolerance, then add cagrilintide at 0.25 mg/week starting Week 9

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