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Conclusion: GLP-1based therapies are associated with predictable GI adverse effects, most of which are mild to moderate and manageable
The underlying pathophysiological mechanism for this remains unknown, but it may be multifactorial due to a combination of gastrointestinal losses, decreased oral intake, and/or increased renal excretion of potassium
While older adults are not the exact population sample of all individuals using GLP-1RA, previous research has correlated muscle loss during 6872 week GLP-1RA treatment to two decades of age-related muscle loss [21]
In addition to directly acting on skeletal muscle to activate AMPK, leptin can also indirectly stimulate AMPK in muscles via -adrenergic signaling from the central nervous system
The MHRA advises caution in patients with pre-existing cardiac conditions, electrolyte disturbances, or those taking other QT-prolonging medications
