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25 As an endocrine hormone, GLP-1 is secreted by enteroendocrine L-cells in the distal jejunum, ileum, and colon in response to food intake and neuroendocrine signals

Each component was selected to support natural metabolic hormone signaling, satiety balance, thermogenic activity, and glucose metabolism

In the STEP-1 trial published in the New England Journal of Medicine , approximately 3840% of total weight lost during semaglutide treatment came from lean mass rather than fat

According to the American Diabetes Association, these medications have become an important component of individualized diabetes care plans

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