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Abbreviations GLP-1: glucagon-like peptide 1 GIP: glucose-dependent insulinotropic polypeptide [Ca 2+ ] i : intracellular Ca 2+ concentrations Adcy: adenylate cyclase CICR: Ca 2+ -induced Ca 2+ release T2D: type 2 diabetes mellitus NOTES

The vascular protective effects of liraglutide were associated with improved plaque stability (14), attenuated endothelial cell dysfunction (14, 15), reduced ICAM-1 expression in the aortic endothelium (12, 15), decreased leukocyte rolling on the endothelium and infiltration of myeloid cells into the vascular wall (13, 16), suppressed foam cell formation (13), and inhibition of vascular smooth muscle cell proliferation (10)

Clinical Evidence for GLP-1 Receptor Agonists in Alzheimers Disease. PubMed Cheng HW et al

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Change in HbA1c, eGFR, and cholesterol levels Biomarker values were assessed in posttreatment selected patients who were alive and had a measurement of the respective biomarker before and 312 months after treatment initiation, as the first available measurement within 12 months after treatment initiation