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Summary SGLT2-i exert more consistent BP-lowering effects than GLP-1RA, largely due to their diuretic-like action

To address the gap in class-wide comparative safety analyses beyond previous studies limited to single drugs or organ systems, this study systematically evaluated adverse events for all approved GLP-1 RAs to identify hidden risks and support clinical decision-making

Among the top blockbuster launches are the GLP-1 brands launched since 2018, as well as transformative first-in-class treatments like Harvoni (Hepatitis C) and Ocrevus (multiple sclerosis)