glp 1 long term safety Long-Term GLP-1 Safety: GI Risks After 3 Years Three major reviews commissioned by

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Adults receiving semaglutide were more likely to report nausea (OR = 1.43

doi:10.1177/20420188231222367 GorgojoMartnez JJ, MezquitaRaya P, CarreteroGmez J, Castro A, CebrinCuenca A, de TorresSnchez A, GarcadeLucas MD, Nez J, Obaya JC, Soler MJ

Although initial findings suggest that GLP-1Ra leads to a slight reduction in bone mineral density and promotes bone remodeling, favoring resorption similar to calorie restriction effects, further research is needed to explore the effects of GLP-1Ra on bone metabolism and fracture-related outcomes, as well as dual- and triple-receptor agonists of GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon in PwO