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Moreover, GLP-1R expression has also been detected in several components of the immune system, such as macrophages, lymphocytes, and invariant natural killer T (iNKT) cells (Song et al., 2017)

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Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)

Recognizing these GLP-1 non-responders promptly allows clinicians to adjust treatment strategies before patients experience prolonged periods without meaningful results, potentially leading to frustration and treatment abandonment

Zepbound (tirzepatide) supports weight loss through its unique dual-action mechanism, targeting both GLP-1 and GIP receptors