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discard if particulate matter or discoloration observed The Most Common Side Effects Nausea Diarrhea Decreased appetite Vomiting Constipation Indigestion Stomach (abdominal) pain The most common adverse reactions reported in 5% of Zepbound-treated patients in placebo-controlled trials were nausea, diarrhea, decreased appetite, vomiting, constipation, dyspepsia, and abdominal pain