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Shaobo Ding, [email protected] These authors have contributed equally to this work This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Review Pathophysiology of AITD Hashimoto Thyroiditis Hashimoto thyroiditis is characterized by a breakdown of immune tolerance to thyroid autoantigens, primarily thyroid peroxidase (TPO) and thyroglobulin (Tg), leading to lymphocytic infiltration of the thyroid gland and progressive tissue damage [1,10]

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Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]

The official website reports that clinical trials have proven the safety and effectiveness