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SNAC raises the pH of the immediate environment around the drug

How Your Body Regulates Temperature During Weight Loss Calorie restriction can reduce basal metabolic rate through adaptive thermogenesis and may suppress thyroid hormone (T3) and leptin levels, all of which lower heat production

Zhang J, Xian TZ, Wu MX, Li C, Pan Q, Guo LX

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To date, no head-to-head studies have been conducted, and caution against drawing final conclusions about comparative efficacy, as contexts of the various studies might not be directly comparable