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Hyperinsulinemia resulting from insulin resistance stimulates excessive androgen production by the ovaries and adrenal glands, exacerbating hyperandrogenemia and ovulatory dysfunction ( e.g ., diet and exercise) and pharmacological treatments ( e.g ., metformin, GLP-1 receptor agonists) can ameliorate insulin resistance and improve metabolic outcomes in PCOS ( 2.3 Hormonal imbalance Hyperandrogenemia is a defining feature of PCOS, characterized by elevated serum testosterone, androstenedione, and dehydroepiandrosterone (DHEA) levels, leading to clinical manifestations such as hirsutism, acne, and alopecia

Dulaglutide: a novel once-weekly glucagon-like peptide-1 receptor agonist

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Calibrators were prepared by spiking blank NHP-plasma with NNC0487-0111 in the range from 0.5200 nM

These symptoms are often more noticeable when starting the medication or increasing the dose (Reference)