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Retatrutide's data come from approximately 338 obesity trial participants followed for 48 weeks
Diabetic nephropathy and antioxidants
Because of this serious risk, drug labels in the GLP-1 category now contain a warning
The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]
Adjustments to the dosing regimen may be necessary based on individual response and tolerance
