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Prophylactic use of anti-emetic medications reduced nausea and vomiting associated with exenatide treatment: A retrospective analysis of an open-label, parallel-group, single-dose study in healthy subjects

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The pathophysiology of pancreatic cancer development with GLP-1 RA use is thought to be secondary to chronic low-grade inflammation and proliferative changes leading to KRAS and p53 gene mutations [85]