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5.3 Lean Mass and Body Composition Weight loss trials indicate that: 2040% of weight lost may include lean mass, depending on protein intake and physical activity. Lean mass loss itself does not cause micronutrient deficiency, but it may reflect: Reduced protein intake Reduced intake of iron- and zinc-rich foods Reduced intake of B vitamins Clinical oversight of protein intake is therefore a practical nutritional priority

Semaglutide can reduce food intake by about 35-40% compared to a placebo

Plaintiffs report persistent vomiting, diarrhea, abdominal pain, and conditions requiring surgical intervention to repair

And thats an impressive reduction

doi: 10.1016/j.diabres.2021.109080