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For some individuals, this downward trend can be associated with a slight return of hunger or cravings a day or two before the next scheduled dose

doi:10.1016/j.autneu.2006.02.015

doi: 10.1016/j.jhsa.2006.03.022

These reductions align with therapeutic goals of 515% weight loss, improving glycaemic control and potentially aiding diabetes remission

Chang et al