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Findings: Between March 15, 2017, and Nov 16, 2018, 788 patients were randomly assigned to semaglutide 10 mg (394 patients) or canagliflozin 300 mg (394 patients)

Therapeutic applications of GLP-1R-targeting nanoplatforms in various human diseases GLP-1R-targeting nanoplatforms have emerged as a versatile and powerful strategy to enhance drug delivery and therapeutic outcomes across a wide range of human diseases

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Typical increases run in the range of about one to four beats per minute for many people, though some report palpitations or a noticeably faster pulse

Type 2 diabetesthe most common indication for GLP-1 therapyis independently associated with a two- to threefold increased risk of ED due to neuropathy, endothelial dysfunction, and reduced nitric oxide availability