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However, as the body adjusts to its new caloric intake, it undergoes a process known as metabolic adaptation the resting metabolic rate decreases in response to reduced energy availability and lower body mass

Cardioprotective effect of SGLT2 inhibitor in Diabetic kidney transplant recipients: a Multicenter Propensity score matched study

The tissue becomes less vascularized, meaning less blood flow reaches the area to carry the medication into systemic circulation
