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In addition to improving satiety or fullness signaling in your brain, GLP-1s also affect your gut by slowing the rate at which you digest, process, and expel food waste

doi: 10.3389/fendo.2021.735019 79 LazzaroniEBen NasrMLoretelliCPastoreIPlebaniLLunatiMEet al

Because the drug has a ~6-day half-life, missing a single weekly injection by a day or two will not collapse your therapeutic drug levels

It is usually worse: right after you start the medicine after a dose increase after a large or greasy meal The good news is that nausea often gets better as your body gets used to the medicine