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In the mesolimbic system, GLP-1R activation has been shown to attenuate the rewarding effects of palatable food and addictive substances, indicating potential therapeutic applications for GLP-1R agonists in treating obesity and SUDs [19,20,21]
Clinical trials comparing the two drugs directly are already underway at Eli Lilly, and that data will eventually inform switching protocols
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This action provides a strong theoretical basis for its inclusion in a mots c retatrutide stack, aiming to optimize cellular energy alongside broader hormonal regulation
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