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Hepatobiliary Events Gallbladder-related adverse events have been observed in retatrutide trials, consistent with observations across GLP-1 agonist studies more broadly

In other CVOTs most patients received target dose (maximal tolerated dose) and no analysis was done regarding dose-dependent effects

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While no established willingness-to-pay threshold exists for weight loss outcomes at 68 weeks, semaglutides lower cost of control and higher efficacy versus liraglutide suggest it is likely to be a cost-effective treatment option

In both types of patients, the combined reduction in the risk of kidney failure, worsening kidney function, and death due to kidney disease was 19%