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From both the mechanistic and clinical standpoints, it is reasonable to expect that GLP-1s and SGLT2s would produce additive CV and renal protective effects

Some women report irregular periods, heavier flow, or cycle changes on GLP-1 medications
Exendin-4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor-kappa B and osteoprotegerin signaling pathway

And so, it's a tough fight, but you're paving the way here
Stop metformin in case of severe infections or impending reduction in renal perfusion When should Insulin be used in Type 2 diabetes mellitus
