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On April 30, 2026, the FDA announced a formal proposal to exclude semaglutide, tirzepatide, and liraglutide from the 503B Bulks List - the regulatory mechanism that governs which bulk substances large-scale 503B outsourcing facilities may use in compounding

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What we know: The same total amount reaches your bloodstream - Clinical trial data confirmed equivalent overall absorption (AUC and Cmax) across all three sites Yet reported side effect rates differed substantially - Thigh showed roughly half the nausea rate of abdomen despite identical systemic exposure Possible explanations include differences in absorption rate (even if total absorption is equal), local tissue effects at the injection site, or simply statistical variation in a relatively small study