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Author contributions RVP and HA were responsible for conceptualization, methodology, writing the original draft, and contributing to critical revision

Berberine activates AMPK indirectly and produces modest metabolic changes, whereas GLP-1 drugs directly stimulate potent receptor signaling with measurable appetite suppression and weight loss

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Billing is done in 12-week cycles with no monthly option

Trial Registration The predefined protocol has been registered in PROSPERO having registration number of CRD42023473991