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Glyceollins, one of the phytoalexins derived from soybeans under fungal stress, enhance insulin sensitivity and exert insulinotropic actions

While gastrointestinal issues are common side effects, the biggest setbacks happen when the patient stops taking a GLP-1

Notably, despite the positive effects on renal outcomes, the study also reported an increased incidence of gastrointestinal side effects, including nausea, vomiting, and diarrhea, though these were not statistically significant [89]

This initiates a cascade that leads to the activation of protein kinase A (PKA), closing of potassium channels, depolarization, and release of calcium from the endoplasmic reticulum.3 An increase of intracellular calcium levels within the cell initiates insulin expression in the nucleus, stimulates energy (ATP) production in the mitochondria, and triggers the release of insulin into the blood stream in a glucose dependent manner (image adapted from Adipogen Life Sciences).4,5 Several commercially and prescribed agents are now available for the management of obesity and type 2 diabetes