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Briefly, in this a double-blind (patient and investigator) study, participants (aged 1875 years) had type 2 diabetes for 6 months or longer (HbA1c 7.0%10.5%), which was inadequately controlled with diet and exercise alone or with stable metformin therapy, and a body mass index of 2350 kg/m 2 (18)

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Emerging research shows that they can: Reduce insulin resistance and improve insulin sensitivity Lower inflammation Reduce testosterone levels Decrease waist circumference and BMI Increase the regularity of ovulation For some women, GLP-1s can be used alongside inositol or metformin

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The systemic nature and widespread prevalence of MASH have led to significant economic burdens, with costs reaching $222.6 billion in the USA in 2017 and up to 19.5 billion in Europe, encompassing both direct (medical care, diagnostic procedures, drugs, hospitalization) and indirect costs (loss of productivity, reduced quality of life, morbidity, and mortality) [11, 12]