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Our research has highlighted that the dysregulated metabolic pathways prevalent in obesity significantly fuel tumor growth and survival, creating an oncogenic environment that diminishes the efficacy of chemotherapeutic agents ( Figure 8 )

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Timing is critical: cramping that begins within days of starting therapy may reflect acute metabolic adjustment, while cramping that emerges weeks later might indicate cumulative electrolyte loss, reduced hydration, or inadequate nutrient intake during weight loss

Some of the most common side effects (but not extremely frequent) are: diarrhea oily stools or spotting stomach discomfort gas more frequent bowel movements that may be hard to control Additional side effects include: loss of appetite diarrhea or constipation increased energy increased thirst dizziness skin rash sexual problems in males chills runny nose irritability or feeling down These symptoms may subside after the body adjusts to the medication