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Within a year, participants regained about two-thirds of the weight they had lost, and said goodbye to some of the improvements in blood pressure, blood sugar and cholesterol they had achieved, according to the landmark STEP 1 extension trial

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Dysregulated neural activity in the CeA is thought to contribute to stress-enhanced consumption of alcohol and palatable food through HPA-dependent and -independent mechanisms [95,96,97,98,99]