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This physiological effect, combined with actions on the central nervous system's area postrema (the brain's vomiting centre), can trigger feelings of queasiness, particularly during the initial weeks of treatment

Semaglutide is the first FDA-approved weight loss medication since 2014

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Although further exploration is needed, the discovery of cinchonine still provides feasible methods and ideas for the development of small-molecule GLP-1R agonists