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[1] The SURMOUNT-5 head-to-head trial confirmed Zepbound produces 47% more weight loss than Wegovy (20.2% vs 13.7% at 72 weeks)

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Therefore, the homeostasis of the gut microbiota environment was significant for the rhythmic secretion of GLP-1 (126)

Nausea occurs in approximately 15-20% of patients and represents the most common side effect, typically emerging during dose escalation and often diminishing over several weeks as tolerance develops