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Costly GLP-1 Drugs Are Rarely Covered for Weight Loss by Marketplace Plans

Shared decision-making, transparent counseling, and multidisciplinary approaches were consistently recommended

Therefore, a cardiovascular safety meta-analysis of data, from all phase 2 and phase 3 clinical trials with planned treatment duration of at least 26 weeks and at least one randomized comparator arm among adults with T2D, was conducted to assess the safety of tirzepatide with regard to major cardiovascular events relative to various randomized comparators

In May 2022, tirzepatide received its first approval in the USA to improve glycaemic control in adults with T2DM, as an adjunct to diet and exercise

It significantly upregulated markers such as MAP2, GAP43, and AGBL4, all of which are associated with neuronal development, axonal growth, and synaptic remodeling
