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Current consensus is that GLP-1 treatment benefits outweigh the risk of EWDR: the drugs reduce the risk of further microvascular damage from poor glycemic control and reduce the chance of death from cardiovascular disease, while the impact on DR is short-lived and can be treated

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The safety profile of semaglutide has been extensively studied outside of AD and is well characterized in T2D and obesity [15, 57,58,59]

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Specifically, the sygl-1 5UTR, the lst-1 5UTR, and the lst-1 start codon have been re-annotated

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