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MCH1R is a typical GPCR that couples to the activation of both G q and G i type G-proteins

A recent nested case-control study based on a French national health insurance system database reported a significant association between thyroid cancer and GLP1 receptor agonist use (hazard ratio 1.46, 95% confidence interval 1.23 to 1.74).7 However, the comparator in that study was non-use of GLP1 receptor agonists, rather than an active comparator

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Thyroid Function Tests (TFTs): Rule out thyroid-related contributors to metabolic dysfunction

Recombinant human GLP-1 inhibits protein kinase C (PKC)-, but increases protein kinase A (PKA), which reduces oxidative stress in both glomeruli and tubules (Yin et al., 2019)