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Several patterns appear consistently: Loss of lean muscle mass Inadequate protein intake Nutrient deficiencies, particularly vitamin D and magnesium This matters because muscle mass plays a direct role in supporting skeletal health
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This finding corroborated our lipidomic analysis, indicating a subset of sphingolipids to show differential abundance among the three mutants

24,188190 In diabetic patients, an increase in filtered glucose of renal proximal tubule was found to enhance SGLT-2 activity, which subsequently worsened glycemic control and promoted Na + loading following impaired blood pressure control

(2019) Nature Medicine, 25:10961103 Drucker DJ
