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Women using oral hormonal contraceptives should be aware that Zepbound may reduce their effectiveness, requiring alternative or backup contraception during initiation and dose escalation periods

A chelator is an organic molecule that can chelate with heavy metal ions

A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

1.4.2 Evidence gap: metabolic proxies as insufficient substitutes for reproductive outcomes Despite the proliferation of guidelines and reviews regarding GLP-1RAs, the majority remain focused on metabolic syndrome, weight management, and cardiorenal protection

[DOI] [PubMed] [Google Scholar] 44.Ebong IA, Goff DC Jr, Rodriguez CJ, et al