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The number of participants using sodium-glucose cotransporter-2 (SGLT2) inhibitors was low at baseline (15%), but that number increased during the trial

This finding underscores the importance of clinical physicians being aware of and conducting comprehensive patient history assessments before prescribing these medications

Within the context of concurrent GLP-1R and GIPR agonism, however, preclinical energy-expenditure models suggest that GCGR engagement may contribute to resting metabolic rate modulation and fatty-acid oxidation in hepatic cell lines

The combined receptor activation produces measurable outcomes distinct from single or dual-receptor activation alone

First, these patients frequently present with endocrinemetabolic disorders such as diabetes or obesity, making perioperative glycemic regulation and metabolic optimization critical