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Therefore, we prioritized univariable MR analysis, which demonstrated a robust association between GLP-1RAs and arrhythmias

It should be noted that GIPR antagonism paradoxically produces additive weight loss when paired to GLP-1R agonism in preclinical studies (5860) and that this mechanism appears relevant in patients with obesity (61)

The Institute of Medicine recommends 38 grams of fiber a day for men age 50 and under and 30 grams a day for older men

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Semaglutide and tirzepatide also enhance secretion of water and electrolytes into the intestinal lumen through GLP-1 receptors in the colon, a mechanism that supports appetite suppression but occasionally produces loose stool consistency