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Dysesthesia Incidence: Retatrutide 9mg: 8.8% Retatrutide 12mg: 20.9% Placebo: 0.7% Importantly, Eli Lilly reported that: Dysesthesia events were generally mild They infrequently led to discontinuation The mechanism is not yet fully understood This side effect was not observed in Phase 2 trials The appearance of dysesthesia at higher doses suggests it may be dose-dependent

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For arthritis, suppression of NF-B, COX-2, and cytokines aligns with reduced joint swelling and inflammatory scores in preclinical models

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