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Pharmacological considerations currently focus on managing associated metabolic and cardiovascular conditions rather than directly treating the liver

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The hallmark of hepatic IR, increased gluconeogenesis, is a key event in the progression of simple steatosis to NASH and progressive fibrosis (164, 165).The TXA2 receptor (TP) stimulates hepatic IR and steatosis through the Ca2+/CaMKII-PERK-CHOP-TRB3 signaling pathway (166)

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El principio activo de Ozempic es la semaglutida, que funciona como sustituto de la hormona humana GLP, responsable de controlar el metabolismo de la glucosa en el organismo, segn explica Rodrigo Lamounier, endocrinlogo y profesor de la Universidad Federal de Minas Gerais (UFMG)