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For GLP-1 users specifically, the fast digestion is a benefit because it spends less time in your already-slow stomach

very slightly soluble in ethanol, acetone, and acetonitrile

If semaglutide made up 80% of GLP-1 volume (before Zepbound), that implies compounded share closer to 32% (source) Now, look at Hims: They launched compounded semaglutide in Q2 2024 and reported $225M in GLP-1 revenue through year-end (source)

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 261,46 per year only 21,79 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Parker, J

Whats even more interesting is that this weight loss occurred in patients who had previously FAILED metformin monotherapy (10)