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The company is also not currently profitable, although as of the latest quarter, it is sitting on a healthy $706 million in cash reserves

Comparison with previous studies The SUSTAIN 9 (Semaglutide once weekly as add-on to SGLT-2i therapy in T2DM) and SURPASS-1 (Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist Tirzepatide in patients with type 2 diabetes) trials demonstrated that both SGLT2i and GLP-1RAs reduced HbA1c and body weight levels compared with placebo in patients with a history of medical treatment for diabetes ( Safety outcomes The SUSTAIN-9 trial demonstrated an association between SGLT2i use and genital and urinary tract infections ( Discrepancies in the SGLT2i or GLP-1RA type and dosage across studies may have influenced the results

A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration

Air EL, Benoit SC, Blake Smith KA, Clegg DJ, Woods SC