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See [expected results timeline](/guides/semaglutide-weight-loss-results-timeline-what-to-expect)

Studies showed a remarkable effect on people with obesity: The SELECT Trial found that MACE (major adverse CVD event) risk was reduced by 20% in adults with obesity without T2D in the group taking semaglutide

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Individual variation is significant: factors like baseline metabolic rate, body composition, ambient temperature, and dose strength all influence symptom severity

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