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Multivar Behav Res 46(3):399424 Carolino IDR, Molena-Fernandes CA, Tasca RS, Marcon SS, Cuman RK N (2008) Risk factors in patients with type 2 diabetes mellitus

2024;326(4):E472EE80

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Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear