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For researchers focused specifically on MASLD, mazdutide offers an excellent risk-benefit profile

Arterioscler Thromb Vasc Biol 42:e168e185

[1] These are surrogate endpoints, not clinical events, and the history of cardiovascular medicine is filled with cautionary tales about therapies that improved surrogate markers without improving outcomes

In conclusion, future research should focus on dissecting mechanisms underlying the effects of serotonin on metabolism directly (locally) and indirectly (systemically) and searching for new targets related with the serotonergic system, to lead to a new era in metabolic health management

Wilcock said using injections could be risky: The trial was made up of mostly older adults, who are often frail and could face health risks if they lost too much weight