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Furthermore, evidence indicates that GLP-1RAs inhibit inflammation in fibroblast-like synoviocytes (FLS) and attenuate RA progression [18], suggesting their potential therapeutic utility in rheumatic disorders [19]

However, some studies suggest that these side effects may be slightly more common or intense with tirzepatide, likely due to its dual-agonist action and higher efficacy

Conversely, no causal link between T2DM and MDD was found in the same studies, supported by other data from a Scottish cohort [61]

According to a survey of elife users, over half of those who experienced side effects reported that their symptoms were gone within one week
