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Studies in rodents have shown that GLP-1 receptor agonists, including semaglutide, cause dose-dependent and treatment-duration-dependent thyroid C-cell tumors

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Appreciating the triple agonist action helps explain why retatrutide might succeed in people that have done poorly on other therapies

doi: 10.1016/j.japh.2019.09.001 [DOI] [PubMed] [Google Scholar] 20.Kang H, Lobo JM, Kim S, Sohn M-W
