glp-1 news november 3 2025 ISPOR 2025: Exploring reasons for discontinuation Beyond GLP-1: the next wave

To this end, we conducted a Region-wide retrospective study on propensity score matched cohorts of patients

The problem is that your first month on a GLP-1 is not one of those jobs it is all of them together

Activation of the GLP-1 receptor (GLP-1R) by GLP-1 stimulates insulin release and inhibits glucagon secretion in a glucose-dependent manner ( 4 )

10.1016/j.obpill.2024.100127 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Nauck MA, Meier JJ (2016) The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

But other drugs (Trulicity, Victoza, Saxenda) and lifestyle interventions that positively affect glucose and weight havent demonstrated these impressive results, Isaacs points out