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Monitoring and adjustment protocols should include: Weight and vital signs at each visit (initially monthly, then quarterly) Assessment of medication tolerance and adherence Evaluation of eating behaviors and physical activity Laboratory monitoring as outlined previously Reassessment of weight-related comorbidities Realistic expectations should be established through shared decision-making

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However, it was forced to "re-evaluate" that decision after demands by the Outsourcing Facilities Association (OFA), a trade group for compounding pharmacists, which sued the agency claiming that tirzepatide was still in short supply

Clinical trials and regulatory bodies, including the MHRA (Medicines and Healthcare Products Regulatory Agency) and the EMA (European Medicines Agency), have approved it for managing diabetes and weight loss[1]

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