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(2021, August 13)
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Since neural circuits ultimately determine feeding behavior, central effects on brain energy homeostatic centers are likely a final common pathway for each of these RYGBP effector mechanisms
However, the -helical extension in TM1 of GIPR provides additional residues for tirzepatide recognition including one hydrogen bond (Y10 P and Q138 1.40b ) and a stacking interaction (K16 P and F127 1.29b )
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