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From 4663 identified articles, 6 met the inclusion criteria, but only one was a randomized controlled trial

Inphase 3 clinical trials (SURPASS 1-5), the dose-dependent efficacy and safety of tirzepatide were assessed by once-weekly subcutaneous injection (5mg, 10mg, and 15 mg), as monotherapy or combination therapy, in individuals with T2DM

A small human proof-of-concept trial reported that semaglutide reduced vastus lateralis cross-sectional area but did not reduce knee-extension strength or grip strength over 12 weeks

GLP-1s, produced in the gut, regulate blood sugar, appetite, and weight