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Efpeglenatide: The AMPLITUDE-O trial (2021) demonstrated a 27% MACE reduction (HR 0.73, 95% CI 0.580.92) in 4076 T2DM patients, with significant reductions in stroke and HF events [19]

DPP-4 inhibitors were not included in the two tiers because their effectiveness on glycemic control is lower than or equivalent to first- and second-tier agents, as well as for less clinical evidence and relative expense

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Endocrinology 137, 29682978